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京都工芸繊維大学大学院工芸科学研究科
Laboratory of Bioregulation Science; KOBORI Group Faculty of Biomolecular Chemistry and Engineering, Kyoto Institue of Technology
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Dual-fluorescent RNA probe with extremely large stokes shifts.
A. Kobori, T. Ueda, Y. Sanada, A. Yamayoshi, A. Murakami.
Biosci. Biotechnol. Biochem. 2013, in press.

Structural imsight for design of inhibitors against RISC function
A. Yamayoshi, Y. Yamada, A. Kobori, A. Murakami.
Chem. Lett. 41, 1684-1685, 2012.

Novel photoresponsive cross-linking oligodeoxyribonucleotides having a caged
a-chloroaldehyde.
A. Kobori, T. Yamauchi, Y. Nagae, A. Yamayoshi, A. Murakami.
Bioorg. Med.Chem., 20, 5071-5076, 2012.

RNA-based diagnosis in a multicellular specimen by whole mount in situ hybridization using an RNA-specific probe.
T. Ueda, A. Kobori, A. Yamayoshi, H. Yoshida, M. Yamaguchi, A. Murakami.
Bioorg. Med. Chem., 20, 6034-6039, 2012.

Synthesis and Crosslinking Activity of 4-N-(4,5’,8-Trimethylpsoralen-4’-ylmethyl)- 2’-deoxycytidine-containing Oligodeoxyribonucleotides.
A. Kobor
i, T. Kohji, Y. Nagae, A. Yamayoshi, A. Murakami.
Chem. Lett., 41, 804-805, 2012.

Surprising Repair Activities of Nonpolar Analogs of 8-oxoG Expose Features of Recognition and Catalysis by Base Excision Repair Glycosylases.
P. L. McKibbin, A. Kobori, Y. Taniguchi, E. T. Kool, S. S. David.
J. Am. Chem. Soc., 134, 1653-1661, 2012.

Real-time Imaging of RNA Expression in Living Cells Using Bispyrene-modified RNA Probes.

R. Waki, A. Yamayoshi, A. Kobori, A. Murakami.
Chem. Lett., 40, 1247-1248, 2011.

Decoy-DNA Against Special AT-Rich Sequence Binding Protein 1 Inhibits the Growth and Invasive Ability of Human Breast Cancer.

A. Yamayoshi, M. Yasuhara, S. Galande, A. Kobori, A. Murakami.
Oligonucleotides, 21, 115-121, 2011.

Development of a system to sensitively and specifically visualize-fos mRNA in living cells using bispyrene-modified RNA probes.

Waki R., Yamayoshi A., Kobori A., Murakami A.
Chem. Commun., 47, 4204-4206, 2011.

Specific regulation of point-mutated K-ras-immortalized cell proliferation by a photo-dynamic antinsense strategy..      
M. Higuchi; A. Yamayoshi; K. Kato; A. Kobori; N. Wake; A. Murakami.
Oligonucleotides,20, 37-4,. 2010.

Sequence selective formation of 1, N6-ethenoadenine in DNA by furan-conjugated probe.
A. Kobori; J. Morita; M. Ikeda; A. Yamayoshi; A. Murakami.
Bioorg. Med. Chem. Lett. 19, 3657-3660, 2009.

Synthesis and Photoinduced Cross-linking Reactions of 4,5',8-Trimethylpsoralen-incorporated Oligodeoxyribonucleotide.
A. Kobori; K. Takaya; M. Higuchi; A. Yamayoshi; A. Murakami.
Chem.Lett., 38, 272-273, 2009.

Synthesis of antisense oligonucleotides containing 2'-O-psoralenylmethoxyalkyl adenosine for photodynamic regulation of point mutations in RNA.
M. Higuchi; A. Kobori; A. Yamayoshi; A. Murakami.
Bioorg. Med. Chem, 17, 475-48,. 2009.

Dimer of 2,7-Diamino-1,8-naphthyridine for the Detection of Mismatches Formed by Pyrimidine Nucleotide Bases.
A. Kobori; and K. Nakatani.
Bioorg. Med. Chem. 16, 10338-10344, 2008.

Efficient synthesis of functionalized oligodeoxyribonucleotides with base-labile groups using a new silyl linker.
A. Ohkubo; R. Kasuya; K. Aoki; A. Kobori; H. Taguchi; K. Seio; M.Sekine.
Bioorg. Med. Chem. 16, 5345-5351, 2008.

Microarray-based label-free detection of RNA using bispyrene-modified 2′-O-methyl oligoribonucleotide as capture and detection probe.
Sakamoto, T., Kobori, A., Murakami, A.
Bioorg. Med. Chem. Lett.,18,2590-2593, 2008

Naphthyridine-tethered oligodeoxynucleotides: Dye/DNA conjugates for homogeneous SNPs assays.
Kobori, A., Mori, T., Ubayashi, M., Murakami. A.
Chem. Lett. 37, 354-355, 2008

Detection of L-DNA-tagged PCR products by surface plasmon resonance imaging.
Hayashi, G., M. Hagihara, M., Kobori, A., Nakatani, K.
Chembiochem, 22, 169-171, 2007

Allele Specific C-Bulge Probes with One Unique Fluorescent Molecule Discriminate the Single Nucleotide Polymorphism in DNA.
Takei, F., Suda, H., Hagihara, M., Zhang, J., Kobori, A., Nakatani, K.
Chemistry - A European Journal, 13, 4452-4457, 2007

Selective Photo-Cross-Linking of 2'-O-Psoralen-Conjugated Oligonucleotide with Rnas Having Point Mutations.
Higuchi, M., Yamayoshi, A., Yamaguchi, T., Iwase, R., Yamaoka, T., Kobori, A., Murakami, A.
nucleosides, nucleotides, nucleic acids, 26, 277-290, 2007

Analysis of mismatched DNA by mismatch binding ligand (MBL)?Sepharose affinity chromatography.
Goto, Y., Suda, H., Kobori, A., Nakatani, K.
Anal. Bioanal. Chem., 388, 1165-1173, 2007

Conformational studies of 4-N-carbamoyldeoxycytidine derivatives and synthesis and hybridization properties of oligodeoxyribonucleotides incorporating these modified bases.
Miyata, K., Kobori, A., Tamamushi, R., Ohkubo, A., Taguchi, H., Seio, K., Sekine, M.
Eur. J. Org. Chem., 16, 3626-3637, 2006

Evaluation of mismatch-binding ligands as inhibitors for Rev-RRE interaction.
K. Nakatani; S. Horie; Y. Goto; A. Kobori; S. Hagihara.
Bioorg. Med. Chem., 14, 5384-5388, 2006

Small-molecule ligand induces nucleotide flipping in (CAG)n trinucleotide repeats.
K. Nakatani; S. Hagihara; Y. Goto; A. Kobori; M. Hagihara; G. Hayashi; M. Kyo; M. Nomura; M. Mishima; C. Kojima.
Nature Chemical Biology, 1, 39-43, 2005

A new ligand binding to G?G mismatch having improved thermal and alkaline stability.
T. Peng; T. Murase; Y. Goto; A. Kobori; K. Nakatani.
Bioorg. Med. Chem. Lett. , 15, 259-262, 2005

N,N'-Bis(3-aminopropyl)-2,7-diamino-1,8-naphthyridine stabilized a single pyrimidine bulge in duplex DNA.
H. Suda; A. Kobori; J. Zhang; G. Hayashi; K. Nakatani.
Bioorg. Med. Chem., 13, 4507-4512, 2005

2-Ureidoquinoline : a useful molecular element for stabilizing single cytosine and thymine bulges.
A. Kobori; T. Murase; H. Suda; I. Saito; K. Nakatani.
Bioorg. Med. Chem. Lett., 14, 3431-3433, 2004

The Binding of Guanine-Guanine Mismatched DNA to Naphthyridine Dimer Immobilized Sensor Surfaces: Kinetic Aspects.
K. Nakatani; A. Kobori; H. Kumasawa; Y. Goto; I. Saito.
Bioorg. Med. Chem., 12, 3117-3123, 2004

The SPR sensor Detection Cytosine-Cytosine mismatches.
A. Kobori; S. Horie; H. Suda; I. Saito; K. Nakatani.
J. Am. Chem. Soc., 32, 278-286, 2004

Detection of guanine-adenine mismatches by surface plasmon resonance sensor carrying naphthyridine-azaquinolone hybrid on the surface.
S. Hagihara; H. Kumasawa; Y. Goto; G. Hayashi; A. Kobori; K. Nakatani.
Nucleic Acids Res., 32, 278-286, 2004

Highly sensitive detection of GG mismatched DNA by surfaces immobilized naphthyridine dimer through poly(ethylene oxide) linker.
K. Nakatani; A. Kobori; H. Kumasawa; I. Saito.
Bioorg. Med. Chem. Lett., 14, 1105, 2007

Unique participation of unprotected internucleotidic phosphodiester residues on unexpected cleavage reaction of the Si - O bond of the diisopropylsilandiyl group used as a linker for the solid-phase synthesis of 5'-terminal guanylated oligodeoxynucleotides.
M. Ushioda; M. Kadokura; T. Moriguchi; A. Kobori; M. Aoyagi; K. Seio; M. Sekine.
Helv. Chim. Acta, 85, 2930-2945, 2002

A new silyl ether-type linker useful for the automated synthesis of oligonucleotides having base-labile protective groups.
A. Kobori; K. Miyata; M. Ushioda; K. Seio; M. Sekine.
Chem. Lett., 1, 16-17, 2002

A New Method for the Synthesis of Oligodeoxyribonucleotides Containing 4-N-Alkoxycarbonyldeoxycytidine Derivatives and Their Hybridization Properties.
A. Kobori; K. Miyata; M. Ushioda; K. Seio; M. Sekine.
J. Org. Chem.,67, 476-485, 2002

Synthesis and hybridization ability of oligodeoxyribonucleotides incorporating N-acyldeoxycytidine derivatives.
T. Wada; A. Kobori; S. Kawahara; M. Sekine.
Eur. J. Org. Chem.,4583-4593, 2001

Theoretical study of the hydrogen bond energy of base pairs formed between substituted 1-methylcytosine derivatives and 9-methylguanine.
S. Kawahara; A. Kobori; M. Sekine; K. Taira; T. Uchimaru.
J. Phys. Chem. A, 105, 10596-10601, 2001

Synthesis and properties of oligodeoxyribonucleotides containing 4-N-acetylcytosine bases.
T. Wada; A. Kobori; S. Kawahara; M. Sekine.
Tetrahedron Lett., 39, 6907-6910, 1998