The utilization of abundant natural resources containing physiologically active compounds available in the Mekong River basin offers a promising approach to promotion of health, a common issue of great concern to us all. Kyoto Institute of Technology (KIT) has been conducting collaborative research projects with eight institutions in four countries of the Mekong River basin with the support of the JSPS Core-to-Core Program. We have already established an insect biomedical research network, in which we identify disease-causative genes and study disease mechanisms using Drosophila insect models. As we are keenly aware of the potential contributions of information and communications technology (ICT) to biological and medical research, our “Natural Physiologically Active Substance Research Network” will strive to develop therapeutic agents and functional foods, and create solutions to our shared issues. We will accomplish this through close collaboration of natural chemistry, biology using insects, and ICT.