Abstract
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Damages of DNA in tritiated water
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Yuji Hatano, Hiroaki Nakamura, Susumu Fujiwara, Seiki Saito, Takahiro Kenmotsu
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Tritium is a radioisotope of hydrogen emitting low energy β-rays in disintegration to 3He. DNA molecules are damaged mainly by β-ray irradiation, and additional damages can be induced by break of chemical bond by nuclear transmutation to inert 3He. Deep knowledges of the mechanisms underlying DNA damages lead to better understanding of biological effects of tritium. This chapter reviews recent experimental and computer simulation activities on quantitative evaluation of damage rates by β-ray irradiation and nuclear transmutation. The rate of DNA double-strand breaks in tritiated water has been examined using a single molecule observation method. The effects of β-ray irradiation were not noticeable at the level of tritium concentration of ~ kBq/cm3, while the irradiation effects were clear at tritium concentrations of ~ MBq/cm3. The factors affecting on the DSB rate are discussed. A new image processing method for the automatic measurement of DNA length using OpenCV and deep learning is also introduced. The effects of tritium transmutation on hydrogen bonds acting between the two main strands of DNA have been examined using molecular dynamics simulations. The study showed that the collapsing of DNA structure by the transmutation can be quantitatively evaluated using the root mean square deviation of atomic positions.
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The Enzymes 51, 131-152 (2022).
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Monte Carlo Simulations of Liquids --- Wetting and Anomalous Relaxation ---
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Kazumi Omata, Susumu Fujiwara, Sohei Gomi and Fumiko Yonezawa
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We develop two typical examples of the Monte Carlo simulations in the
study of liquids, one from the macroscopic viewpoint and the other from
the microscopic viewpoint. As the former, we investigate wetting phenomena
by numerically solving the Navier-Stokes equation and show that the
finger instabilities take place as a result of submacroscopic fluctuations.
As the latter, we study anomalous relaxation in disordered systems and
show that the Cole-Cole form and the Kohlraush law are respectively
outcomes of the fractal and non-fractal structures.
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Computational Physics as a New Frontier in Condensed Matter
Research, Eds. H. Takayama, M. Tsukada, H. Shiba, F. Yonezawa,
M. Imada and Y. Okabe (The Physical Society of Japan, 1995) pp. 321-328.
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Complex Fluids: Anomalous Relaxation, Percolation and Wetting
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Fumiko Yonezawa, Susumu Fujiwara, Sohei Gomi and Kazumi Omata
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Our recent research on complex fluids is reviewed. This article is divided
into three parts. The first part is devoted to some theoretical models
of the anomalous relaxation observed in various kinds of disordered systems.
In the second part, percolation theory, by which disordered systems are also
modeled, is focused and, in particular, we report on the determination of
percolation threshold with high accuracy. In the last section, we discuss a
topic concerning wetting which is an old but developing research area of
complex fluids.
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Elementary Processes in Dense Plasmas, Eds. S. Ichimaru
and S. Ogata (Addison-Wesley Pub. Co., 1995) pp. 323-334.
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Anomalous Relaxation in Supercooled Liquids
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Susumu Fujiwara and Fumiko Yonezawa
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We survey a short history on anomalous relaxation and review experimental
results, theoretical and computer simulation analyses on supercooled liquids.
We explain our models for anomalous relaxation within one-body picture.
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Solid State Physics 29, 412-417 (1994). (in Japanese)
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In Quest of the Mechanisms of Anomalous Relaxation --- Monte Carlo simulations
of random walk in spaces of fractal dimension ---
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Susumu Fujiwara and Fumiko Yonezawa
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Monte Carlo simulations of random walk in spaces of fractal dimension are
performed. We focus our attention on the relaxation processes and show
that the complex susceptibility turns out to be Cole-Cole type.
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Solid State Physics 29, 418-424 (1994). (in Japanese)
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Chaotic Mixing by Kneading
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Susumu Fujiwara and Alfred Hübler
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We study the mixing process of kneading dough experimentally and model it
with a simple area-preserving map ("mixing map"). This map is characterized
by a parameter rsm (1/2
rsm 1), which represents the
ratio of "stretching" to "moving", and a map with rsm=1
corresponds to a baker's transformation. We analyze mixing properties of
this map by applying the diagnostics of mixing used by I. Zawadzki and
H. Aref (Phys. Fluids A 3, 1405 (1991)). We find that mixing is very
efficient at rsm=1 but degrades rapidly nearby. However at
rsm 3/4 mixing is as
efficient as a baker's transformation. Accidentaly, this parameter region
rsm 3/4 is achievable
experimentaly.
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Center for Complex Systems Research Technical Report CCSR-94-18 (1994).
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Copyright (C) 1996-2024
Susumu Fujiwara